An initial report of quantitative analysis of segmented whole-brain MRSI in epilepsy
Motivation: Our motivation is to study neurochemical changes using Magnetic Resonance Spectroscopic Imaging (MRSI) in MR-negative patients with epilepsy whose structural MRI fails to reveal the Seizure Onset Zone (SOZ). Goal(s): Regionally analyzing the MRSI maps for different metabolites in the main lobes of the brain. Approach: Finding the median of Concentration Estimates (CE), we defined the highest relative difference between left and right hemisphere to highlight asymmetries which we compared with the clinically defined SOZs. Results: We found a relationship between neurochemical asymmetries and SOZ in 7 out of 10 patients. Impact: For the first time, we established regional concentration estimates of neurochemicals in epilepsy patients using 7T MRSI. Detecting abnormal concentrations could improve the diagnostic performance in MR-negative patients.
Authors
- Stefanie Chambers (ORCID: https://orcid.org/0009-0006-7463-6636)
- Ekaterina Pataraia (ORCID: https://orcid.org/0000-0002-1454-7600)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Haniye Shayeste (ORCID: https://orcid.org/0000-0002-9706-7775)
- Lukas Haider (ORCID: https://orcid.org/0000-0002-1556-1770)
- Gregor J. Kasprian (ORCID: https://orcid.org/0000-0003-3858-3347)
- Matthias Tomschik (ORCID: https://orcid.org/0000-0002-6243-1178)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Johannes Koren (ORCID: https://orcid.org/0000-0002-5290-2837)
- Martha Feucht (ORCID: https://orcid.org/0000-0001-7691-8158)
- Jonathan Wais
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Christian Dorfer
- Karl Rössler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Leo Hofer
- Christoph Baumgartner
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2945
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00