Correlation Study between Cognitive Impairment and Bone Marrow fat fraction in Cranial and Lumbar Vertebrae fat fraction

Motivation: Whether quantitative bone marrow fat scores are associated with cognitive function. Goal(s): To determine the correlation between cognitive function and skull and vertebral bone marrow fat fraction. Approach: Applying the mDIXON-Quant technique to assess bone marrow fat fraction in the cranial and lumbar vertebrae, and examining its correlation with cognitive impairment. Results: A negative correlation is observed between the fat fraction of the cranial and vertebral bones and the Mini-Mental State Examination (MMSE) scores. Impact: The quantitative fat fraction of bone marrow in the cranium and vertebrae is associated with cognitive impairment.，This may provide a signature research direction for the bone-brain axis.