Renal Spatial Profile of IVIM Parameters: Humans and Dogs

Motivation: While renal IVIM is well-studied in humans, there is limited data for dogs and no direct human-dog comparisons. Understanding interspecies similarities and spatial heterogeneity in IVIM values could clarify the suitability of dogs as a model for human kidney research. Goal(s): Evaluate spatial heterogeneity of renal IVIM parameters across renal regions in both humans and dogs. Identify interspecies similarities and differences. Approach: Nine human participants and eight healthy beagles were scanned with similar DWI sequences (same b-values s/mm2). Divide each kidney in different anatomical regions. Evaluate IVIM parameters differences between regions. Results: Significant differences were identified among different renal regions. Impact: This study enhances understanding of IVIM parameter variation across renal regions from cortex to medulla and cranial-caudal direction in humans and dogs, providing insights into intrarenal diffusion dynamics and expands data availability for the IVIM canine community.