Study on the Mechanism of Cognitive Impairment in NMOSD Patients Mediated by the Reorganization of FC Related to Iron Metabolism Abnormalities
Motivation: The mechanisms of cognitive impairment in NMOSD patients are not yet clear. Goal(s): To investigate how abnormal iron metabolism reorganizes functional connectivity networks and correlates with cognitive impairment using combined QSM and rs fMRI. Approach: Participants underwent QSM imaging to assess DGM iron concentration and rs fMRI for brain network analysis. Results: Higher iron concentration in GPe may affect its communication with the right precentral gyrus and is associated with cognitive impairment in NMOSD patients. Impact: This study provides a new perspective on elucidating the neural mechanisms of cognitive impairment in NMOSD patients through the combined use of QSM and rs fMRI techniques.
Authors
- Liangjie Lin (ORCID: https://orcid.org/0000-0002-3174-3136)
- Yuxi Liu (ORCID: https://orcid.org/0009-0008-2821-4963)
- Fuxin Ren (ORCID: https://orcid.org/0000-0001-8561-6549)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-4507-5351)
- Jing Wang (ORCID: https://orcid.org/0000-0002-8117-8657)
- Xi Li (ORCID: https://orcid.org/0000-0002-7167-8332)
- Bing Liu (ORCID: https://orcid.org/0000-0003-4010-8334)
- Fei Gao (ORCID: https://orcid.org/0000-0003-1010-3567)
- Xiaoxia Lin
- Fuyan Li (ORCID: https://orcid.org/0000-0002-5020-5237)
- Longji Xu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3160
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00