MRI OEF and CMRO₂ in Predicting Ischemic Lesion Survival in Acute Stroke: New insight on Diffusion Reversibility
Motivation: Our study examines OEF and CMRO₂ as markers of tissue viability in AIS cases with "ghost core," where ischemic core is overestimated on MRI. Goal(s): This study aims to determine if elevated pretreatment OEF and CMRO₂ predict DWI lesion reversibility in acute ischemic stroke, aiding treatment decisions. Approach: This study used a retrospective voxel-based analysis of pretreatment OEF and CMRO₂ maps and posttreatment MRI to assess metabolic markers associated with DWI lesion reversibility after reperfusion. Results: Our findings show that recovered ischemic tissue depicted by reversal of reduced diffusion have significantly higher OEF and CMRO₂ values in comparison to tissue which remained infarcted. Impact: Pretreatment MR OEF and CMRO₂ markers in AIS patients can predict diffusion reversibility within the estimated ischemic core. This approach can refine the ischemic core assessment for reperfusion therapy selection and potentially improving clinical outcomes through tailored treatment strategies.
Authors
- Luis Emilio Savastano (ORCID: https://orcid.org/0000-0002-9881-1594)
- Kazim Narsinh (ORCID: https://orcid.org/0000-0002-2019-5461)
- Christopher Hess
- Cathra Halabi (ORCID: https://orcid.org/0000-0002-0331-8183)
- Kambiz Nael (ORCID: https://orcid.org/0000-0002-4194-9488)
- Ahmad Fadzil Ismail (ORCID: https://orcid.org/0000-0002-3321-8546)
- David S Liebeskind
- Steven W. Hetts (ORCID: https://orcid.org/0000-0001-5885-7259)
- Nerissa Ko (ORCID: https://orcid.org/0000-0002-3439-0559)
- Mersedeh Bahr Hosseini (ORCID: https://orcid.org/0000-0003-3049-4542)
- Geoffrey Philip Colby (ORCID: https://orcid.org/0000-0002-3376-0933)
- Jeffrey L. Saver (ORCID: https://orcid.org/0000-0001-9141-2251)
- Wade S. Smith (ORCID: https://orcid.org/0000-0003-4174-8333)
- Viktor Szeder (ORCID: https://orcid.org/0000-0003-0703-8258)
- Anirudh Sreekrishnan (ORCID: https://orcid.org/0000-0001-7251-7189)
- Vivek Srikar Yedavalli (ORCID: https://orcid.org/0000-0002-2450-4014)
- Pouya Metanat (ORCID: https://orcid.org/0000-0003-2905-4080)
- Mona Asghariahmadabad
- Anthony Kim (ORCID: https://orcid.org/0000-0002-8095-6517)
- S Josephson
- Elham Tavakol
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2526
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00