Mapping brain regional differences in young rats with chronic liver disease using fast 1H-FID-MRSI at 9.4T
Motivation: Type C hepatic encephalopathy (HE) is increasingly suspected in children with chronic liver disease (CLD) and various brain regions might be affected. Goal(s): To investigate the potential of 1H-FID-MRSI to detect metabolic and brain regional changes in a model of CLD during brain development and maturation. Approach: Bile duct ligated and sham rats operated at p21 days after birth underwent 1H-FID-MRSI 6-weeks post-ligation at 9.4T. Results: Using 1H-FID-MRSI, we detected and mapped the metabolic changes in the developing brain with CLD, investigated brain regional changes, and proved the potential of 1H-FID-MRSI to detect small changes due to individual animal response to disease. Impact: Our study demonstrated the potential of 1H-FID-MRSI at 9.4T to detect and map metabolic changes in the developing brain in a rat model of chronic liver disease, specifically regional differences and changes in Gln due to individual response to disease.
Authors
- Dario Sessa
- Valérie A. McLin (ORCID: https://orcid.org/0000-0002-0711-687X)
- Stefanita Mitrea
- Bernard Lanz (ORCID: https://orcid.org/0000-0001-5136-075X)
- Thanh Phong Lê (ORCID: https://orcid.org/0000-0002-9615-5642)
- Jessie Mosso (ORCID: https://orcid.org/0000-0001-6318-9507)
- Cristina Cudalbu (ORCID: https://orcid.org/0000-0003-4582-2465)
- Gianna Nossa (ORCID: https://orcid.org/0009-0009-2745-9464)
- Brayan Alves
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2927
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00