MR Spectroscopy using the Intraoperative MR System

Motivation: Intraoperative magnetic resonance spectroscopy (ioMRS) has rarely been applied, although it offers high potential. It could be introduced to MR-guided laser-induced thermal therapy (MRgLITT) for improving cancer treatment. Goal(s): The aim was to compare two MRS sequences measured with a conventional and an intraoperative (io) coil at different brain regions. Approach: 10 healthy subjects were measured at 3T with a conventional and an io coil using a PRESS and sLASER sequence in the cingulate gyrus and amygdala. Results: Better spectral quality was gained with the conventional coil in regions closer to the coil. No differences in concentrations were found between the coils. Impact: Intraoperative MR spectroscopy (ioMRS) is feasible and has been performed for the first time with an sLASER sequence. Future implementation in MR-guided laser-induced thermal therapy (MRgLITT) allows tracking of metabolic changes due to LITT.