Multiparametric functional MRI of the kidneys in healthy subjects before and after water intake.

Motivation: Multiparameter MR metrics are sensitive to fluid transport in the kidney induced by diuretic challenges [1]. However, widely accepted reference values remain limited, and the impact of hydration status on specific MRI parameters is not yet fully understood. Goal(s): Evaluation of functional MRI parameters of the kidneys throughout the day in the healthy renal cortex and medulla before and after water intake. Approach: Ten volunteers underwent two MRI examinations on the same day. The multiparametric MRI protocol includes ASL, IVIM, BOLD, MT, T1 and T2 mapping. Results: Changes observed in certain MRI parameters may reflect parenchymal alterations in healthy kidneys after hydration. Impact: Our study showed that the multiparametric functional MRI of the kidneys can help evaluate the renal function depending on its hydration status and may play an important role in kidney imaging.