Multimodal virtual brain: when hd-EEG drives simulations of brain dynamics closer to patients’ reality
Motivation: The creation of virtual brain models able to fit individual resting-state fMRI (rs-fMRI) time series is needed, aiming to obtain digital twins of patients useful for clinical translation. Goal(s): In this work we develop a multimodal virtual brain for a group of mild cognitive impairment patients, a new step towards the creation of patients' digital twins. Approach: For each subject hd-EEG data were integrated in the multimodal virtual brain together with structural connectivity to drive brain dynamics simulations. Results: Multimodal virtual brain revealed its superior ability to fit rs-fMRI time series recorded in patients. Impact: With its capacity to perform simulations closer to reality, this new model opens new prospectives in the use of virtual brains as digital representations of patients, a crucial tool for the development of personalized interventions.
Authors
- Anna Pichiecchio (ORCID: https://orcid.org/0000-0002-5654-4088)
- Lisa Maria Farina (ORCID: https://orcid.org/0000-0002-4993-0415)
- Fulvia Palesi (ORCID: https://orcid.org/0000-0001-5027-8770)
- Alfredo Costa (ORCID: https://orcid.org/0000-0001-7312-8011)
- Stefano Francesco Cappa (ORCID: https://orcid.org/0000-0003-1003-3925)
- Francesca Conca (ORCID: https://orcid.org/0000-0003-1809-6541)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Michele Terzaghi (ORCID: https://orcid.org/0000-0001-9692-2218)
- Anna Castelnovo (ORCID: https://orcid.org/0000-0002-8875-9657)
- Egidio D’Angelo (ORCID: https://orcid.org/0000-0002-6007-7187)
- Elena Capriglia (ORCID: https://orcid.org/0009-0008-1109-2285)
- Paolo Antonino Grasso (ORCID: https://orcid.org/0000-0002-5456-6822)
- Matteo Cotta Ramusino (ORCID: https://orcid.org/0000-0003-3090-9648)
- Agnese Augello (ORCID: https://orcid.org/0000-0001-6463-9151)
- Anita Monteverdi (ORCID: https://orcid.org/0000-0003-0071-9325)
- Giuseppe Calia
- Chiara Totaro
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3142
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00