Clonidine Conserves Sleep Spindle Properties and Age-Dependent Electroencephalogram Patterns Mirroring Physiologic Sleep in Infants Under Spinal Anesthesia
Our findings suggest that low-dose clonidine does not impact sleep spindle properties in the EEG of infants under spinal anesthesia. The EEG of infants under spinal anesthesia demonstrate age-related changes that mirror quiet physiologic sleep. In addition, the presence of intrathecal clonidine has no effect on the age-related changes in the EEG pattern. Clonidine is an adjunct for spinal anesthesia in infants that appears to prolong anesthetic duration without affecting their EEG patterns of physiologic sleep.
Authors
- Mingjian He (ORCID: https://orcid.org/0000-0002-6688-8693)
- Andrew L. Chen (ORCID: https://orcid.org/0000-0002-2291-7974)
- Johanna M. Lee
- Christian S. Guay (ORCID: https://orcid.org/0000-0001-6744-5248)
- Uday Agrawal (ORCID: https://orcid.org/0000-0003-3899-316X)
- Jack S. Elder (ORCID: https://orcid.org/0000-0001-5309-0490)
- Chang Amber Liu (ORCID: https://orcid.org/0000-0003-3760-0002)
- Rodrigo G. Gutiérrez
- Patrick L. Purdon
- Alexis Novak (ORCID: https://orcid.org/0009-0004-5445-8313)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1213/ane.0000000000007763
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86