Genome-Wide DNA Methylation Profiles of Long-Term Cognitive Decline after Delirium in Intensive Care Unit Patients
This genome-wide DNAm analysis focused on LTCD after delirium highlights differentiating epigenetic signals related to MHC class II and immune processes. These findings provide initial evidence that epigenetic processes may play a crucial role in the pathophysiological mechanisms underlying LTCD after delirium.
Authors
- Kyosuke Yamanishi (ORCID: https://orcid.org/0000-0001-5130-8193)
- Tetsufumi Kanazawa (ORCID: https://orcid.org/0000-0003-3781-297X)
- Christopher G. Hughes (ORCID: https://orcid.org/0000-0002-9261-5875)
- Pratik P. Pandharipande (ORCID: https://orcid.org/0000-0002-1389-8580)
- Takehiko Yamanashi (ORCID: https://orcid.org/0000-0002-3881-8997)
- Gen Shinozaki (ORCID: https://orcid.org/0000-0001-6129-2789)
- Tsuyoshi Nishiguchi (ORCID: https://orcid.org/0000-0002-8230-8804)
- Yoshitaka Nishizawa
- Tomoteru Seki (ORCID: https://orcid.org/0000-0003-2593-7118)
- Masaaki Iwata (ORCID: https://orcid.org/0000-0002-6143-0181)
- Summer S. Qureshi
Institutions
- University of Iowa (US)
- Hyogo Medical University (JP)
- Tokyo Medical University (JP)
- Palo Alto University (US)
- Tottori University (JP)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
- Osaka University of Pharmaceutical Sciences (JP)
- Stanford University (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1213/ane.0000000000007749
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00