Resting Metabolic And Cardiometabolic Biomarker Changes After L-BAIBA And Grains Of Paradise Supplementation

Dietary supplement approaches to support weight loss, fitness, and body composition continue to be popular. Beta-amino-isobutyric acid (BAIBA), a myokine, supports fat loss in animal models while grains of paradise, a member of the ginger family, may support health through modulation of glucose, triglycerides, and cholesterol components. PURPOSE: To evaluate the impact of 8 weeks of supplementing with L-BAIBA or L-BAIBA + Grains of Paradise on resting metabolic rate and cardiometabolic markers in conjunction with a diet and exercise program in overweight and obese men and women. METHODS: 37 healthy men and women (43.2 ± 11.4 years, 169.4 ± 7.6 cm, 90.3 ± 15.6 kg, 31.4 ± 4.4 kg/m2) completed a weekly exercise program while reducing their energy intake and were randomly assigned in a double-blind manner to consume daily either a placebo, 500 mg L-BAIBA (MitoBurn, NNB Nutrition), or 500 mg L-BAIBA +40 mg Grains of Paradise (CaloriBurn, NNB Nutrition). After 0, 2, 4, and 8 weeks of supplementation, participants were evaluated for changes in resting metabolic rate while fasted and 60 minutes after dose ingestion, resting heart rate and blood pressure, total cholesterol, glucose, triglycerides, and LDL cholesterol. Mixed factorial ANOVA with repeated measures were used to evaluate main and interaction effects. A p-value of 0.05 was used to determine statistical outcomes. RESULTS: Resting metabolic rates (kcals/day) increased across time (p = 0.005) but were similar between groups across the study period (Day 0: 1672 ± 266, Day 14: 1659 ± 209, Day 28: 1703 ± 231, Day 56: 1737 ± 278, p = 0.238). Resting metabolic rate responses after acute ingestion were similar in magnitude between groups (Day 14: -14.7 ± 142.9, Day 28: 35.1 ± 157.0, Day 56: 46.5 ± 160.0, p = 0.777). Additionally, no changes were observed between groups in systolic blood pressure (p = 0.890), diastolic blood pressure (p = 0.123), heart rate (p = 0.886), total cholesterol (p = 0.624), glucose (p = 0.498), triglycerides (p = 0.155), and LDL cholesterol (p = 0.671). CONCLUSION: Supplementation with BAIBA or BAIBA+GOP did not impact baseline resting metabolic rate levels nor acute changes in resting metabolic rate 60 minutes after ingestion. Furthermore, no changes were reported in common markers of cardiometabolic health after supplementation. Supported by: NNB Nutrition, Nanjing, China