Association between sleep disturbances and gray matter volume in individuals at clinical high-risk for psychosis and healthy controls: A longitudinal MRI study (NAPLS-3)
Our findings indicate no association between sleep disturbances and gray matter volume in CHR-P individuals or HC. This negative result suggests that sleep problems, though prevalent and predictive of psychosis risk, likely act through mechanisms other than structural brain changes, underscoring their value as accessible targets for early intervention.
Authors
- Merel Koster (ORCID: https://orcid.org/0009-0009-4014-757X)
- Babet N. Wezenberg
- Lieuwe de Haan (ORCID: https://orcid.org/0000-0002-3820-7926)
- Marieke van der Pluijm (ORCID: https://orcid.org/0000-0003-0665-7911)
- Guido van Wingen (ORCID: https://orcid.org/0000-0003-3076-5891)
Institutions
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Schizophrenia Research
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1016/j.schres.2025.09.010
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Mental Health