Lower non-invasive estimated P <sub>mus</sub> predicts extubation failure in mechanically ventilated ICU patients
We evaluated whether non-invasive estimated inspiratory muscle pressure (P<sub>mus</sub>) predicts extubation outcomes in ICU patients. Estimated P<sub>mus</sub>, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated P<sub>mus</sub> (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (P<sub>L,dyn</sub>) showed no significant association. Estimated P<sub>mus</sub> offers a simple bedside method to assess inspiratory muscle strength and may help identify patients at risk of extubation failure. Further multicenter studies are needed to validate these findings.
Authors
- Ewan C. Goligher (ORCID: https://orcid.org/0000-0002-0990-6701)
- Geovana Téo Zamprogna (ORCID: https://orcid.org/0009-0000-9382-5869)
- Antuani Rafael Baptistella (ORCID: https://orcid.org/0000-0003-1708-9921)
- Gustavo Bruno Rático
- Manoela Bonato Zocoli
- Silvano Altair do Nascimento
- G Müller (ORCID: https://orcid.org/0009-0004-4307-7515)
- Jéssica Magnante
Institutions
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Universidade do Oeste de Santa Catarina (BR)
- Toronto General Hospital Research Institute
Publication Details
- Journal
- Journal of the Intensive Care Society
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1177/17511437251377989
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00