Modeling of mixed infection with Zika and West Nile viruses (<i>Flaviviridae</i>: <i>Orthoflavivirus</i>: <i>Orthoflavivirus zikaense, Orthoflavivirus nilense</i>) <i>in vitro</i> and <i>in vivo&l

The presence of <i>in vitro</i> interference between the studied orthoflaviviruses was shown, most pronounced in relation to the Zika virus. No significant effect was observed with simultaneous co-infection <i>in vivo</i>. However, pre-infection of mice with Zika virus provides protection to animals from lethal WNV infection due to the induction of high levels of antibodies that specifically neutralize its infectious activity.