Effects Of Exercise On Improving Cognitive Function In MCI: An Umbrella Review Of Systematic Review And Meta-analysis

PURPOSE: To investigate the effects of exercise intervention on improving cognitive function in patients with Mild Cognitive Impairment (MCI). METHODS: We conducted a general review of existing meta-analyses of randomized controlled trials (RCTs) on the effects of exercise interventions on cognitive function in elderly patients with MCI.The literature was searched via PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. According to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), evidence of each outcome was evaluated and graded as “high”, “moderate”, “low” or “very low” quality to draw conclusions. Additionally, we classified evidence of outcomes into 4 categories. RESULTS: We identified 10 RCT meta-analyses from 5634 independent articles. High quality evidence shows that Exergaming( SMD 0.67,95%Cl 0.23, 1.11), Traditional Chinese Exercises (TCEs) (SMD 0.32 95% CI 0.18 to 0.47), and Tai Chi (SMD o.36 95% CI 0.18 to 0.54)can significantly improve cognitive function in patients with MCI.These are moderate-quality evidence. Exercise(SMD 1.25, 95% CI 0.88 to 1.62), multi-component exercises(SMD 1.165, 95% CI 0.741 to 1.589), aerobic exercise(MD 1.23, 95% CI 0.99 to 2.47), the variety of exercises(SMD 0.65, 95% CI 0.39 to 0.91), combining cognitive and physical training(SMD 1.40, 95% CI 0.85 to 1.96), dance(MD 1.24, 95% CI 0.30 to 2.18), Baduanjin(MD 3.37, 95% CI 2.05 to 4.69) can significantly improve MMSE and MoCA scores, indicating exercise's potential to improve cognitive function in MCI patients. CONCLUSION: There is high to moderate evidence that Exergaming, Aerobics, Mind-Body Exercises, Cognitive and Physcial training, and Multiple Exercise are effective in improving cognitive function in people with MCI.Keywords: exercise, MCI, cognitive function, umbrella review, meta-analysis, systematic review