Associations Of Actigraphy-assessed Sleep Variables With Cardiometabolic Outcomes In Emerging Adults

PURPOSE: Evidence suggests insufficient sleep (e.g., short sleep duration, poor sleep efficiency) is associated with increased cardiometabolic risk (CMR). Yet data on sleep and CMR in emerging adults (ages-18-25 years) is limited. We assessed cross-sectional associations between actigraphy-assessed sleep with CMR outcomes in emerging adults. METHODS: Data were collected from 145 emerging adults (age = 19.4 ± 1.3 years; fat mass index (FMI) = 7.8 ± 5.8 kg/m2; 57.8% female; 65.3% White) from the RIGHT Track Health study. Actigraphy-based sleep measures included sleep duration (minutes/day) and sleep efficiency (sleep duration/time in bed; %). CMR outcomes included mean arterial pressure (MAP), and the following indices created using simple summation to assess cumulative risk: inflammatory index (interleukin (IL)-1 beta, IL-6, IL-10, tumor necrosis factor-alpha, interferon-gamma), clotting index (plasminogen activator inhibitor-1, anti-thrombin-lll), acute phase reactant index (CRP, uric acid, monocyte chemoattractant protein-1), and lipid index (triglycerides, total cholesterol). Linear regression models adjusted for age, sex, race, and FMI were used to measure associations. Akaike information criterion (AIC) determined the model of best fit. RESULTS: Mean sleep duration was 5.4 hours/night, while mean sleep efficiency was 86.9%. Sleep duration was positively associated with MAP (B = 0.089, [-0.0000424, 0.0002165 at 95%CI], p < 0.001), the clotting index (B = 0.006, [-0.0004595, 0.0004916 at 95%CI], p = 0.019), and the lipid index (B = 0.012, [-0.0004379, 0.0005152 at 95%CI], p < 0.001), while sleep efficiency was inversely associated with MAP (B = -0.060, [-0.003281, 0.00124 at 95%CI], p < 0.001), the clotting index (B = -0.68, [-0.01183, 0.005325 at 95%CI], p = 0.014) and the lipid index (B = -0.2, [-0.02010, -0.002890 at 95%CI]; p < 0.001). Both sleep duration (B = -0.124, [-0.0009468, 0.0001090 at 95%CI], p < 0.001) and sleep efficiency (B = -0.078, [-0.01435, 0.004840 at 95%CI], p < 0.001) were also inversely associated with the acute phase reactant index. The inflammatory index was not associated with either sleep outcome. CONCLUSION: These data suggest that greater sleep efficiency, but not longer sleep duration, may be protective for CMR in emerging adults. Supported by: Supported by NIH Grant R01 HD078346-01A1