Granulated barium titanate/ ꞵ-tricalcium phosphate/collagen scaffolds: preparation and characterization for bone tissue engineering

Abstract A spray drying technique was applied to prepare granulated BT/β-TCP (bariumtitanate/ β-tricalcium phosphate) powders with various compositions, and then the granulated BT/β-TCP/collagen scaffolds were prepared using the freeze-drying method. Our experimental results showed that the values of compressive modulus for the 22.5, 45.0, and 67.5wt% β-TCP-contained scaffolds were 2.29±0.11, 3.20±0.25, and 3.39±0.39 MPa, respectively, which are much higher than that of the pure collagen scaffold (compressive modulus of 1.58 ± 0.23 MPa). In addition, the 22.5wt% β-TCP-contained scaffold only degrades 9.5% after 28 days, compared to 100% degradation of the pure collagen scaffold. Finally, this study explored the relationships between porosity, mechanical properties, and biodegradation behavior of granulated BT/β-TCP/collagen scaffolds.