Sarcomatoid Carcinoma in a Resected Hepatic Metastasis of Esophageal Squamous Cell Carcinoma after Chemotherapy
This case highlights the rare phenomenon of histological transformation of squamous cell carcinoma to sarcomatoid carcinoma within a metastatic site, emphasizing the importance of surgical resection for both diagnosis and treatment. The loss of BRM/SMARCA2 may have contributed to the epithelial-mesenchymal transition-driven transformation and, together with neuroendocrine differentiation, may have played a role in the tumor's aggressiveness. Histological reassessment of chemotherapy-resistant lesions is crucial for elucidating tumor evolution and optimizing future therapeutic strategies.
Authors
- Tomohiro Suzuki (ORCID: https://orcid.org/0000-0002-6008-4440)
- Kentaro Kato (ORCID: https://orcid.org/0000-0001-5820-3263)
- Noriaki Kyogoku
- Yusuke Tsunetoshi (ORCID: https://orcid.org/0000-0002-6981-6812)
- Yoshiyasu Ambo (ORCID: https://orcid.org/0000-0003-1981-8403)
- Chiho Goto (ORCID: https://orcid.org/0000-0001-5645-8852)
- Naoya Okada (ORCID: https://orcid.org/0000-0002-1443-9191)
- Yuko Omori (ORCID: https://orcid.org/0009-0004-8285-5340)
- Hirokatsu Katagiri (ORCID: https://orcid.org/0000-0002-4567-6106)
- Saki Kawaguchi
- Yusuke Asai (ORCID: https://orcid.org/0000-0003-2979-3449)
- Zenya Naito
- Takumi Yamabuki (ORCID: https://orcid.org/0000-0002-8129-1991)
- Ryo Koyama (ORCID: https://orcid.org/0009-0007-4157-1634)
- Hiroyuki Yamamoto (ORCID: https://orcid.org/0009-0001-5658-4960)
- Yoshihiro Kinoshita
- Minoru Takada (ORCID: https://orcid.org/0000-0002-3394-4302)
- Kotaro Kimura (ORCID: https://orcid.org/0000-0002-3379-3890)
Institutions
- Teine Keijinkai Hospital (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.70352/scrj.cr.25-0257
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00