Extracellular vesicles derived from irradiated oral squamous cell carcinoma cells inhibits M2 macrophage polarization by the miR-198-5p/MYD88 axis
Our findings indicate that EVs rich in miR-198-5p derived from irradiated OSCC cells inhibit M2 polarization of macrophages through inhibition of MYD88 expression; thus suggesting that encapsulating miR-198-5p within EVs may represent a promising therapeutic strategy for OSCC.
Authors
- Mingli Duan
- Yongdong Zhang (ORCID: https://orcid.org/0000-0002-1151-1792)
- Ronghua Li (ORCID: https://orcid.org/0000-0002-8282-3232)
- Xiao-Ming Du
Institutions
- Tianjin First Center Hospital (CN)
- Tianjin Stomatological Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1080/09553002.2025.2498981
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00