Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context
Our study demonstrates that the post-SCI environment dampens IL-13 efficacy on microglia. Taken together these data caution against simple immunomodulatory strategies and suggest that effective polarisation of microglia in vivo will require multimodal approaches.
Authors
- Dearbhaile Dooley
- James P. Reynolds (ORCID: https://orcid.org/0000-0003-1536-1557)
- Christopher Carew (ORCID: https://orcid.org/0000-0002-9257-5762)
- Ross O'Carroll (ORCID: https://orcid.org/0000-0002-1841-6966)
- Emmanuelle Damilola Aiyegbusi
- Robert Colbert
Institutions
- University College Dublin (IE)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1007/s00011-025-02089-2
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84