Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder
Patients with iRBD exhibit a reduced DTI-ALPS index, suggesting altered glymphatic function. This reduction was associated with future phenoconversion to PD, supporting the DTI-ALPS index as a potential prognostic MRI biomarker of progression in prodromal synucleinopathies.
Authors
- Christina Tremblay (ORCID: https://orcid.org/0000-0002-7747-8147)
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Marie Vidailhet (ORCID: https://orcid.org/0000-0002-2409-9143)
- Shady Rahayel (ORCID: https://orcid.org/0000-0001-5786-3278)
- Johannes Klein (ORCID: https://orcid.org/0000-0002-8553-2801)
- Ronald B. Postuma (ORCID: https://orcid.org/0000-0002-6468-4734)
- Véronique Daneault (ORCID: https://orcid.org/0000-0002-8950-9043)
- Stanislav Mareček (ORCID: https://orcid.org/0009-0004-0773-5373)
- Alexandre Pastor‐Bernier (ORCID: https://orcid.org/0000-0002-8865-6551)
- Celine Haddad
- Marie Filiatrault
- Violette Ayral
- Stéphane Lehéricy
- Marie Vidaillhet
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université du Québec à Montréal (CA)
- Charles University (CZ)
- Montreal General Hospital (CA)
- Nuffield Orthopaedic Centre (GB)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Institut du Cerveau (FR)
- Université de Montréal (CA)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1212/wnl.0000000000214042
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55