On a continuum model for random genetic drift: a dynamic boundary condition approach

We propose a new continuum model for random genetic drift by employing a dynamic boundary condition approach. The model can be viewed as a regularized version of the Kimura equation and admits a continuous solution. We establish existence and uniqueness of a strong solution to the regularized system. Numerical experiments illustrate that, for sufficiently small regularization parameters, the model can capture key phenomena of the original Kimura equation, such as gene fixation and conservation of the first moment.

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Publication Details

Journal
Communications in Analysis and Mechanics
Published
2025-01-01
DOI
https://doi.org/10.3934/cam.2025033
Primary Topic
RNA Research and Splicing
Type
article
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article

On a continuum model for random genetic drift: a dynamic boundary condition approach

Jan-Eric Sulzbach, Chun Liu, Yiwei Wang
Communications in Analysis and Mechanics
RNA Research and Splicing
article

On a continuum model for random genetic drift: a dynamic boundary condition approach

Jan-Eric Sulzbach, Chun Liu, Yiwei Wang
article en

Abstract

We propose a new continuum model for random genetic drift by employing a dynamic boundary condition approach. The model can be viewed as a regularized version of the Kimura equation and admits a continuous solution. We establish existence and uniqueness of a strong solution to the regularized system. Numerical experiments illustrate that, for sufficiently small regularization parameters, the model can capture key phenomena of the original Kimura equation, such as gene fixation and conservation of the first moment.

Communications in Analysis and MechanicsVol. 17(3)
University of California, Riverside (US), Illinois Institute of Technology (US), Technical University of Munich (DE)
Openalex Percentile: Top 78%
RNA Research and Splicing
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