Prolactin secreting pituitary neuroendocrine tumors treated by dopamine agonists: predictors of response
Normalization of PRL levels is a practical and reliable predictor of treatment response. A combined radiological assessment using both tumor diameter and volume is advisable: diameter offers greater insight in the early stages, while volume becomes more informative in the mid- to long-term follow-up. In patients with persistently elevated PRL levels and lack of radiological response, alternative management strategies-including surgical resection-should be considered, especially in light of recent evidence supporting the cost-effectiveness of surgery in enclosed prolactinomas.
Authors
- Sara Catenazzi
- Gianluca Aimaretti (ORCID: https://orcid.org/0000-0002-6186-0106)
- Chiara Mele (ORCID: https://orcid.org/0000-0003-2880-9373)
- Paolo Marzullo (ORCID: https://orcid.org/0000-0003-3215-5747)
- Rosa Pitino (ORCID: https://orcid.org/0000-0002-2685-3090)
- Simona Baldi (ORCID: https://orcid.org/0000-0002-8296-4238)
- Marina Caputo (ORCID: https://orcid.org/0000-0003-0470-9343)
- Martina Romanisio
- Flavia Prodam (ORCID: https://orcid.org/0000-0001-9660-5335)
- Alice Ferrero (ORCID: https://orcid.org/0000-0001-9464-3223)
- Marco Zavattaro
- F. Rosmini
- Sara Sturnia
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fendo.2025.1664621
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29