In vitro assessment of laser-ablated nanoparticles' cytotoxicity against different oral cancer cells

Oral cancer is an international health problem that has few treatment methods and a negative prognosis in late cases. The potential cytotoxicity of laser-ablated gold-silver and copper nanoparticles was considered in this study and the effects were tested on oral squamous cell carcinoma cell lines (SCC-4, CAL-27, KB-3-1) and normal human oral keratinocytes (HOK). The most cytotoxic was gold nanoparticles (IC 50: 38.9-45.1 0g/mL) with a marked selectivity (p < 0.001), causing apoptosis, as which flow cytometry and morphological analysis were confirmed. The statistical results obtained were moderate for silver and copper nanoparticles. These results present laser-ablated gold as a potential oral cancer anticancer agent that is specific.