Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis
Our results identify a previously unrecognized role of the TGFβ-ARKADIA-SKI axis in regulating the stability and functionality of human Treg subsets, highlighting novel strategies for harnessing TGFβ-associated pathways to stabilize human Treg cells for clinical applications.
Authors
- Yasuhiro Ikeda (ORCID: https://orcid.org/0000-0002-2970-7304)
- Kyle J. Bednar (ORCID: https://orcid.org/0000-0001-5804-3415)
- Fan Yang (ORCID: https://orcid.org/0000-0003-4821-6583)
- Zengli Guo (ORCID: https://orcid.org/0000-0003-2950-4790)
- Patrick J. Heizer
- Tatiana Ort
- Alexis A. Yanes
- Miao Li (ORCID: https://orcid.org/0000-0002-4360-1960)
- M.F.C. Stephens
- Yang Song (ORCID: https://orcid.org/0009-0002-4380-2065)
- Ivan Linatoc
Institutions
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Japan) (JP)
- AstraZeneca (Finland) (FI)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1636434
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca