Protective effects of Shenkang injection against diabetic kidney disease via p38 MAPK/NFκB/MCP-1/CCR2 pathway inhibition
SKI can reduce kidney inflammatory damage in db/db mice, improve kidney function, and delay the progression of diabetes. The mechanism may involve the reduction of MCP-1/CCR2 activation through the p38 MAPK/NFκB signaling pathway.
Authors
- Kaidong Zhou
- Ge Jin (ORCID: https://orcid.org/0000-0002-8517-7969)
- Xin Zhou (ORCID: https://orcid.org/0000-0003-1076-1033)
- Yanmo Cai
- Sitong Wang (ORCID: https://orcid.org/0000-0002-5448-8166)
- Zongjiang Zhao
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fendo.2025.1596000
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56