Screening and characterization of DNA aptamers that modulate prime editing
Our study demonstrates that Cas9-specific aptamers can effectively enhance prime editing efficiency. This provide new insights into the modulation of prime editing and hold potential for improving its clinical applications.
Authors
- Xinbo Huang (ORCID: https://orcid.org/0000-0002-9500-4586)
- Jing Ye
- Xia Wu (ORCID: https://orcid.org/0000-0002-8151-8076)
- Mingxia Wang (ORCID: https://orcid.org/0000-0003-2340-8941)
- Yaoting Gui
Institutions
- Peking University Shenzhen Hospital (CN)
- Skin Research Center (FR)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fmolb.2025.1565459
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00