Research Progress on Trimethoprim Cyclodextrin Inclusion Complexes

Trimethoprim (TMP), as a broad-spectrum bacteriostatic antibiotic, is widely used in clinical anti-infection therapy and livestock breeding. However, its low water solubility leads to insufficient bioavailability, which has become a key problem restricting its development. Cyclodextrins and their derivatives, with their unique cyclic structures, can form inclusion complexes with TMP to improve its properties. This article reviews the pharmacological characteristics of TMP, the types and properties of common cyclodextrins, focusing on introducing various preparation methods of trimethoprim cyclodextrin inclusion complexes and multiple characterization methods for identifying the inclusion complexes, aiming to provide a reference for further research and development of trimethoprim cyclodextrin inclusion complexes.