Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV
PLHIV on ART had higher DNA damage-related markers despite having comparable ROS levels than their age-matched controls. The immunotherapeutic potential of chaetocin for reversing premature aging as well as HIV latency needs to be explored further.
Authors
- Ujjwala Ghule
- Avinash Sonawane (ORCID: https://orcid.org/0000-0002-9596-2629)
- Rohini Bingewar
- Jyoti Sawant (ORCID: https://orcid.org/0000-0003-1702-3631)
- Pallavi Shidhaye (ORCID: https://orcid.org/0000-0002-3903-2830)
- Amrita Rao (ORCID: https://orcid.org/0000-0003-2950-9938)
- Manisha Ghate (ORCID: https://orcid.org/0000-0003-4222-4611)
- Ashwini Shete (ORCID: https://orcid.org/0000-0003-0791-2128)
- Smita Kumbhar (ORCID: https://orcid.org/0000-0002-3030-9477)
- P. Chavan
- Rajani Bagul
- Sathi Koar
Institutions
- National AIDS Research Institute (IN)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fragi.2025.1658506
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Council of Medical Research