Assessment of urate-lowering therapies on lipid metabolism and kidney function in non-dialysis chronic kidney disease patients: 12 months multicenter cohort study
In this cohort study of non-dialysis CKD patients, ULT use was associated with improved lipid profiles reduced LDL-c, TG, and TC; increased HDL-c, with greater HDL-c elevation and LDL-c reduction in males. ULTs exposure also correlated with attenuated CKD progression. These findings suggest potential interactions between SUA and lipid metabolism, highlighting ULTs' possible role in managing dyslipidemia and renal function decline in pre-dialysis CKD.
Authors
- Huanhuan Yin (ORCID: https://orcid.org/0000-0002-5183-5898)
- Disheng Wang
- Dong Sun (ORCID: https://orcid.org/0000-0002-4546-404X)
- Yasir Waheed (ORCID: https://orcid.org/0000-0002-5789-4215)
- Xinglei Zhou (ORCID: https://orcid.org/0000-0002-3734-7898)
- Karthick Kumaran Munisamy Selvam
- Jie Liu (ORCID: https://orcid.org/0000-0003-1398-5411)
- Shulin Li (ORCID: https://orcid.org/0009-0009-6647-1167)
- S. Farrukh
- Shifaa Almayahe
- Maryam Bishdary
Institutions
- Central Michigan University (US)
- Xuzhou Medical College (CN)
- University Of Fallujah (IQ)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
- Xuzhou No.1 People's Hospital (CN)
- Cixian People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fendo.2025.1592290
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University