Effects of hypoxia/hyperoxia exposure on immune function – results from a spacecraft-relevant hypobaric chamber study
These data indicate that, similar to living at high altitude, altered atmosphere exposure in a pressurized vehicle environment may dysregulate human immunity which may be exacerbated by EVAs. The additive effects of hypoxia, in concert with other spaceflight mission variables, on clinical risks for astronauts must be better characterized to enable future exploration class space missions.
Authors
- Thomas Oswald (ORCID: https://orcid.org/0009-0001-6333-058X)
- Alejandro Garbino (ORCID: https://orcid.org/0000-0003-0761-0816)
- Sara R. Zwart (ORCID: https://orcid.org/0000-0001-8694-0180)
- Satish Mehta (ORCID: https://orcid.org/0000-0003-4198-3261)
- Brian E. Crucian
- Karina Marshall‐Goebel (ORCID: https://orcid.org/0000-0002-5240-7625)
- Patrick Estep (ORCID: https://orcid.org/0009-0005-8621-1494)
- Scott M. Smith (ORCID: https://orcid.org/0000-0001-9313-7900)
- Douglass M. Diak
- Sara Bustos-Lopez
- Cody Gutierrez
- Millennia Young
- Audrie A. Colorado
- Monica Y Hew-Yang
Institutions
- KBR (United States) (US)
- AEgis Technologies (United States) (US)
- GeoControl Systems (United States) (US)
- Johnson Space Center (US)
- JES Tech (United States) (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fphys.2025.1637834
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00