Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms
These results demonstrate that C5 possesses a multifunctional mechanism of action, combining direct bactericidal activity through membrane targeting with anti-biofilm efficacy and immunomodulatory properties. This multifaceted profile highlights its strong potential as a promising candidate for combating resistant bacterial infections.
Authors
- Zheng Qu (ORCID: https://orcid.org/0000-0001-7885-4629)
- L T Hu
- Yaguang Liu (ORCID: https://orcid.org/0000-0002-1926-444X)
- Binbin Liu (ORCID: https://orcid.org/0000-0001-9454-6984)
Institutions
- Qinhuangdao Second Hospital (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fchem.2025.1654358
- Citations
- 1
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94