Cold-water immersion alleviates intestinal damage induced by exertional heat stroke via modulation of gut microbiota in rats
The metabolites inosine, taurine, hypoxanthine, and guanosine correlated with restored gut microbiota, reduced proportion of <i>Desulfovibrio</i>, and attenuated inflammation (lower LPS/Lac), suggesting that their dual role in mitigating intestinal damage. These findings underscore the therapeutic potential of CWI by modulating microbial-derived metabolites, highlighting its impact on the intestinal health of patients with EHS.
Authors
- Xiaojun Sun
- Lanlan Xuan (ORCID: https://orcid.org/0000-0002-2496-7676)
- Yuhao Yi (ORCID: https://orcid.org/0000-0001-6036-0276)
- Guifeng Zhao (ORCID: https://orcid.org/0000-0001-8837-0142)
- Handing Mao (ORCID: https://orcid.org/0000-0003-1603-3205)
- Yuxi Wang (ORCID: https://orcid.org/0009-0004-3022-8716)
- Feng Chen (ORCID: https://orcid.org/0000-0002-7092-8483)
- Yuxiang Zhang (ORCID: https://orcid.org/0000-0002-4075-3950)
- Jiaxing Wang (ORCID: https://orcid.org/0000-0002-6674-4948)
- Baozhong Wang
Institutions
- Chinese PLA General Hospital (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- Heilongjiang Provincial Hospital (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Microbiomes
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/frmbi.2025.1531991
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00