Case Report: Coronary vasospasm precipitating STEMI and polymorphic ventricular tachycardia—a case of cardiotoxicity from 5-FU based chemotherapy in a 41-year-old woman
In an unusual fashion, our patient developed ST-segment elevation myocardial infarction (STEMI) caused by coronary vasospasm, followed by delayed polymorphic ventricular tachycardia approximately 24 h later. This dual-phase presentation and subsequent successful rechallenge with bolus-based 5-FU chemotherapy have not been previously reported.
Authors
- Mohammed Al-Yafi
- Aaron Hesselson (ORCID: https://orcid.org/0000-0002-7384-770X)
- Amit Arbune
- Kristin Ellison
- Zachary Neace
- Ammar Hasnie
- Karam Ayoub
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fcvm.2025.1594338
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05