Proangiogenic effects of peritumoral adipose tissue in kidney cancer
We show that renal peritumoral adipose tissue secretes VEGF and promotes angiogenesis on HUVEC cell lines, suggesting that VEGF, among other factors, may contribute to this effect. This proangiogenic stimulus would promote the vascularization of the tumor, favoring its growth and metastasis.
Authors
- Rubén W. Carón (ORCID: https://orcid.org/0000-0002-8223-9140)
- Flavia Bruna (ORCID: https://orcid.org/0000-0003-2309-0398)
- Leonardo Romeo
- Fiorella Campo Verde Arboccó (ORCID: https://orcid.org/0000-0002-4071-2315)
- Nadia Bannoud (ORCID: https://orcid.org/0000-0001-8540-5995)
- Diego O. Croci (ORCID: https://orcid.org/0000-0002-8623-0645)
- Virginia Pistone‐Creydt
- Matías Ferrando
- Constanza Matilde López‐Fontana
Institutions
- University of Mendoza (AR)
- Universidad Nacional de Cuyo (AR)
- Instituto Tecnológico de Buenos Aires (ITBA) (AR)
- Instituto de Histología y Embriología de Mendoza (AR)
- Centro Científico Tecnológico - Mendoza (AR)
- Instituto de Medicina y Biología Experimental de Cuyo (AR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fmed.2025.1652589
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Universidad Nacional de Cuyo
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación