Base-promoted cascade annulation and annulation/carboxylation of α-enolizable phosphoryl substituted ynones and isatins with CO<sub>2</sub>
A base-catalyzed cascade reaction of isatins and α-enolizable phosphoryl substituted ynones has been developed leading to spiroindolin-2-ones. The reaction is an anion-anionic domino process, where an unprecedented interception of the vinyl anion by the intermediate CO<sub>2</sub> was achieved to obtain spiroindolin-2-ones bearing a phosphonoacetate fragment.
Authors
- I. P. Beletskaya (ORCID: https://orcid.org/0000-0001-9705-1434)
- А.Н. Ефремов (ORCID: https://orcid.org/0000-0002-2329-4684)
- Alexander Yu. Mitrofanov (ORCID: https://orcid.org/0000-0003-3141-3599)
- Arina V. Murashkina (ORCID: https://orcid.org/0000-0002-4288-8912)
- Victoria E. Gontcharenko (ORCID: https://orcid.org/0000-0001-6290-8880)
- Andrei V. Bogdanov (ORCID: https://orcid.org/0000-0002-2483-4742)
- Alexander E Savoskin
Institutions
- National Research University Higher School of Economics (RU)
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04158a
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00