Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. Int. Ed. 41/2025)
Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.
Authors
- Andrea Capucciati (ORCID: https://orcid.org/0000-0002-2731-3547)
- Niklas Wallstein (ORCID: https://orcid.org/0009-0003-4952-7962)
- Luigi Casella (ORCID: https://orcid.org/0000-0002-7671-0506)
- Luigi Zecca (ORCID: https://orcid.org/0000-0002-7409-6653)
- Enrico Monzani (ORCID: https://orcid.org/0000-0002-8791-6446)
- Andreas Pöppl (ORCID: https://orcid.org/0000-0003-2354-2542)
- Carsten Jäger (ORCID: https://orcid.org/0000-0001-6512-9903)
- Fabio A. Zucca (ORCID: https://orcid.org/0000-0003-1230-1129)
- Michela Sturini (ORCID: https://orcid.org/0000-0002-8122-6188)
- Harald E. Möller (ORCID: https://orcid.org/0000-0002-5659-1925)
- André Pampel (ORCID: https://orcid.org/0000-0002-9319-5016)
- Claudia S. Schnohr (ORCID: https://orcid.org/0000-0002-3688-7104)
Institutions
- University of Pavia (IT)
- Gruppo Italiano per lo Studio dei Carcinomi dell’Apparato Digerente (IT)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Institute of Biomedical Technologies (IT)
- Leipzig University (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1002/anie.202519533
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00