Increased circulating Th17 cells and altered CD4 T cell maturation and differentiation in active tuberculosis with type 2 diabetes: a pilot study
This pilot study reveals CD4 T cell alterations in T2D that likely worsen TB outcomes. A reduced naïve CD4 T cell pool, increased central memory and antigen-activated CD4 T cells, and elevated Th1 and three Th17 cell subsets suggest a pro-inflammatory environment favoring responses that may promote, rather than control TB. These findings highlight immune dysfunctions that could be targeted by host-directed therapies to prevent TB and improve outcomes in T2D patients.
Authors
- Génesis P. Aguillón-Durán
- Raúl Loera-Salazar
- Paul Ogongo (ORCID: https://orcid.org/0000-0002-0093-5768)
- Esperanza M. García-Oropesa (ORCID: https://orcid.org/0000-0002-4803-1143)
- Yoscelina Estrella Martínez-López (ORCID: https://orcid.org/0000-0002-9481-3381)
- America M. Cruz-Gonzalez
- Javier E. Rodríguez-Herrera
- Luis A. Garza (ORCID: https://orcid.org/0000-0002-6547-9695)
- Blanca I. Restrepo (ORCID: https://orcid.org/0000-0002-3743-9098)
- Cecilia S. Lindestam Arlehamn (ORCID: https://orcid.org/0000-0001-7302-8002)
- J. Ernst (ORCID: https://orcid.org/0000-0001-9951-6207)
- Anthony Tran (ORCID: https://orcid.org/0000-0002-5570-6436)
- A Sette
- Ilse A. Dominguez-Trejo
Institutions
- Statens Serum Institut (DK)
- Texas Biomedical Research Institute (US)
- La Jolla Institute for Immunology (US)
- University of California, San Francisco (US)
- The University of Texas Rio Grande Valley (US)
- University of California System (US)
- University of California San Diego (US)
- Universidad México Americana del Norte (MX)
- Autonomous University of Tamaulipas (MX)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1637868
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Institutes of Health
- University of California, San Francisco
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases