Cohort study finds glucocorticoids increase risk of anxiety, depression

A population‐based cohort study using both self‐controlled and target trial emulation approaches has reported an association between use of oral glucocorticoids and increased risk of adverse psychiatric outcomes. Use of glucocorticoids was found to be associated with higher risk of depressive, bipolar, and anxiety disorders but did not increase risk of suicidality.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-09-09
DOI
https://doi.org/10.1002/pu.31359
Primary Topic
Stress Responses and Cortisol
Type
article
Field-Weighted Citation Impact
0.00
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article

Cohort study finds glucocorticoids increase risk of anxiety, depression

The Brown University Psychopharmacology Update
Stress Responses and Cortisol
article

Cohort study finds glucocorticoids increase risk of anxiety, depression

article en

Abstract

A population‐based cohort study using both self‐controlled and target trial emulation approaches has reported an association between use of oral glucocorticoids and increased risk of adverse psychiatric outcomes. Use of glucocorticoids was found to be associated with higher risk of depressive, bipolar, and anxiety disorders but did not increase risk of suicidality.

The Brown University Psychopharmacology UpdateVol. 36(10)
Openalex Percentile: Top 74%
Stress Responses and Cortisol
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Cohort study finds glucocorticoids increase risk of anxiety, depression · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS