Augmentation with pramipexole efficacious for treatment‐resistant depression

Augmenting antidepressant treatment with the dopamine D2/D3 receptor agonist pramipexole led to improvement in depressive symptoms relative to placebo at 12 weeks in patients with treatment‐resistant depression, a randomized trial has found. Treatment discontinuation due to adverse events was more prevalent in the pramipexole group, investigators reported. Study results were published online June 29, 2025, in Lancet Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-09-09
DOI
https://doi.org/10.1002/pu.31355
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
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Augmentation with pramipexole efficacious for treatment‐resistant depression

The Brown University Psychopharmacology Update
Treatment of Major Depression
article

Augmentation with pramipexole efficacious for treatment‐resistant depression

article en

Abstract

Augmenting antidepressant treatment with the dopamine D2/D3 receptor agonist pramipexole led to improvement in depressive symptoms relative to placebo at 12 weeks in patients with treatment‐resistant depression, a randomized trial has found. Treatment discontinuation due to adverse events was more prevalent in the pramipexole group, investigators reported. Study results were published online June 29, 2025, in Lancet Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(10)
Openalex Percentile: Top 72%
Treatment of Major Depression
DOISourceOpenAlex
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Augmentation with pramipexole efficacious for treatment‐resistant depression · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS