Successful Desensitization with Ixekizumab in a Patient with a History of Multiple Biological Agent Allergy

Biological agents, widely used in the treatment of oncologic, immunologic, and rheumatologic diseases, have long-term effects in reducing mortality rates and disease burden.Targeted biological agents are of great importance due to their higher efficacy and lower side effects.For patients with a history of hypersensitivity reactions or at risk of developing such reactions to these agents, drug desensitization is considered an appropriate treatment option.In this case report, Ixekizumab was successfully administered to a 53-year-old female patient with a history of allergies to several biological agents through desensitization.The drug was given without premedication, using three different solutions in a 7-step protocol over 90 minutes.This process was successful despite the patient's previous hypersensitivity reaction to Ixekizumab.