Synthesis, pharmacokinetic studies, and metabolite analysis of meridianin C in rats using a validated ultra high performance liquid chromatography-tandem mass spectrometry method
These findings demonstrate that the primary metabolic pathway of MC involves hydroxylation (phase I) followed by conjugation (phase II). To our knowledge, this represents the first systematic investigation of the pharmacokinetic characteristics of MC and its metabolites in rats. The study not only advances understanding of MC disposition but also provides a valuable reference for future pharmacokinetic evaluations of other marine-derived indole alkaloids.
Authors
- Liangyu Xu (ORCID: https://orcid.org/0000-0003-4850-2504)
- Karna Ramachandraiah (ORCID: https://orcid.org/0000-0002-0102-1060)
- Guihun Jiang (ORCID: https://orcid.org/0000-0002-0816-2667)
- Guozhe Zhang (ORCID: https://orcid.org/0000-0002-8966-473X)
- Zhaogen Wu
Institutions
- Jiangsu Vocational College of Medicine (CN)
- Jilin Medical University (CN)
- Louisiana State University Health Sciences Center New Orleans (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fphar.2025.1633157
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province
- Education Department of Jilin Province