NGHIÊN CỨU KHẢ NĂNG GÂY BỆNH CỦA CHỦNG VIRUS DỊCH TẢ LỢN CHÂU PHI VNUA/HY-ASF1 QUA ĐƯỜNG TIÊM BẮP Ở LỢN THÍ NGHIỆM

African swine fever (ASF) is a highly infectious disease in pigs caused by virus with mortality rate of up to 100%. This study evaluated the pathogenicity of the VNUA/HY/ASF1 virus strain via intramuscular injection in 8-week-old pigs. The pigs were divided into three experimental groups (TN1, TN2, TN3) with respective virus doses of 102, 103, and 104 HAD50/pig, along with a control group that was not exposed to the virus. Results showed that all pigs in the three infected groups died within 5 to 13 days post-injection. The mean time to death for the TN1, TN2, and TN3 groups was 11.2 ± 1.3 days, 7.4 ± 1.8 days and 7.2 ± 1.8 days, respectively. Typical clinical symptoms, including high fever, anorexia, lethargy, and reduced activity, were observed in all infected pigs. Pigs exposed to higher virus doses exhibited earlier symptoms, reflecting a faster disease progression. However, multi-organ hemorrhagic lesions, particularly in the spleen, lymph nodes, and kidneys were more severe in pigs infected with lower virus doses due to the prolonged disease course. This study confirms the high virulence of the VNUA/HY/ASF1 strain.