THE ROLE OF PREOPERATIVE NEUTROPHIL TO LYMPHOCYTE RATIO AND PTEN IMMUNOHISTOCHEMICAL EXPRESSION IN ENDOMETRIAL BIOPSIES – A TWO YEAR STUDY

Endometrial cancer (EC) is the most common and second most dangerous gynaecological cancer among women in the United States however in India, the rates are as low as 4.3 per 100,0001. Endometrial hyperplasia (EH) is the ideal benign counterpart for endometrioid carcinoma while atypical hyperplasia is a precursor lesion. Neutrophil-lymphocyte ratio (NLR) is known to be a marker of Inammation. Increased NLR is found to have worse overall-survival in EC2-3.Therefore, NLR is a cheap, easy, simple, and reproducible marker to distinguish the endometrial pathologies including normal, hyperplasia without atypia, hyperplasia with atypia, and endometrial cancer. PTEN (Phosphate and TENsin homolog deleted on chromosome 10) gene expression is normally present in the cyclical endometrial conditions which are oestrogen rich.Thus its tumour suppressor function is decreased which is directly proportional to cancer risk particularly in high estrogenic states4-5. Immunohistochemistry study of PTEN expression is an effective screening method for endometrial carcinoma. In our study, NLR was found signicantly higher in EC among endometrial pathologies and PTEN negative immunoreactivity was detected in the majority of EC and atypical hyperplasia. NLR was foun Summary: d signicantly higher in EC among endometrial pathologies. Thus, NLR can be used to discriminate EC from other endometrial pathologies including endometrial hyperplasia and normal endometrial ndings.