Wenxin Keli regulates energy metabolism and improves Cx43 via the AMPK/SIRT1/PGC-1α pathway
Wenxin Keli exhibits multi-target regulation of energy metabolic disorders in post-myocardial infarction heart failure while protecting Cx43. Its core mechanism is activating the AMPK/SIRT1/PGC-1α signalling pathway and its downstream regulatory network.
Authors
- Xiaonan Cui (ORCID: https://orcid.org/0000-0002-4019-6680)
- Jiuli Zhao (ORCID: https://orcid.org/0000-0002-3634-0416)
- Lixia Lou (ORCID: https://orcid.org/0000-0002-3035-8009)
- Ding Yang (ORCID: https://orcid.org/0000-0001-5341-7510)
- Bo Nie (ORCID: https://orcid.org/0000-0002-8608-3542)
- Aiming Wu (ORCID: https://orcid.org/0000-0002-2746-5532)
- Zhe Wang (ORCID: https://orcid.org/0000-0001-9117-7917)
- Yizhou Zhao (ORCID: https://orcid.org/0000-0001-8237-1734)
- Shaoqing Zheng
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fphar.2025.1624595
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- National Natural Science Foundation of China