Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients

Psychotic and affective disorders, including schizophrenia (SCZ) and depression (MDD), affect millions of people globally. The overlapping symptoms of these diseases and the lack of objective diagnostic tools could lead to misdiagnosis. Recent studies suggest that the analysis of plasma lipid levels may help to develop new diagnostic tools. In this study, we investigated the plasma lipidome of psychiatric patients and healthy controls to identify disease-specific lipid species. Using untargeted mass spectrometry, we profiled blood plasma lipids from 416 patients with common psychotic and affective disorders and 272 healthy individuals from two different cohorts. We observed lipidome alterations in SCZ and MDD consistent with earlier findings. In total, 144 lipids showed significant changes, with 107 of them being concordant across both disorders, and 37 being discordant. Lipids that differentiated SCZ from MDD were mainly triacylglycerols with polyunsaturated fatty acid residues decreased in MDD. In an additional group of 111 patients with bipolar, schizotypal, and schizoaffective disorders, these lipid markers suggested a trend toward separating psychotic and affective disorders. Furthermore, a logistic regression model trained on lipid data distinguished SCZ from MDD with an ROC AUC of 0.83. Taken together, these results suggest that blood lipid profiling may aid in the objective differentiation of psychotic and affective disorders.

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Publication Details

Journal
Biomolecules
Published
2025-09-09
DOI
https://doi.org/10.3390/biom15091296
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients

Аnna Morozova, A. V. Serkina, Daria Petrova, A M Reznik et al.
Biomolecules
Metabolomics and Mass Spectrometry Studies
article

Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients

Аnna Morozova, A. V. Serkina, Daria Petrova, A M Reznik, Elena Stekolshchikova, Daria Riabinina, И. Ф. Тимербулатов, Philipp Khaitovich, Anastasia Golubova, Denis Andreyuk, Inessa Yu. Akhmerova, А. Э. Гареева, Valeria Zakurazhnaya, Anna Tkachev
article en

Abstract

Psychotic and affective disorders, including schizophrenia (SCZ) and depression (MDD), affect millions of people globally. The overlapping symptoms of these diseases and the lack of objective diagnostic tools could lead to misdiagnosis. Recent studies suggest that the analysis of plasma lipid levels may help to develop new diagnostic tools. In this study, we investigated the plasma lipidome of psychiatric patients and healthy controls to identify disease-specific lipid species. Using untargeted mass spectrometry, we profiled blood plasma lipids from 416 patients with common psychotic and affective disorders and 272 healthy individuals from two different cohorts. We observed lipidome alterations in SCZ and MDD consistent with earlier findings. In total, 144 lipids showed significant changes, with 107 of them being concordant across both disorders, and 37 being discordant. Lipids that differentiated SCZ from MDD were mainly triacylglycerols with polyunsaturated fatty acid residues decreased in MDD. In an additional group of 111 patients with bipolar, schizotypal, and schizoaffective disorders, these lipid markers suggested a trend toward separating psychotic and affective disorders. Furthermore, a logistic regression model trained on lipid data distinguished SCZ from MDD with an ROC AUC of 0.83. Taken together, these results suggest that blood lipid profiling may aid in the objective differentiation of psychotic and affective disorders.

BiomoleculesVol. 15(9)
Lomonosov Moscow State University (RU), Russian New University (RU), Kemerovo State Medical University (RU), Ufa Institute of Chemistry (RU), Russian Medical Academy of Continuous Professional Education (RU), Bashkir State Medical University (RU), Federal Medical Research Centre for Psychiatry and Narcology (RU), Moscow State University (TJ), Mental Health Research Center of Russian Academy of Medical Sciences (RU), Academy of Sciences of the Republic of Bashkortostan (RU), National Research Institute of Public Health named after N.A. Semashko (RU), Research Center of Neurology (RU), Federal State Budgetary Institution "Center for Expertise and Quality Control of Medical Care" (RU), Kemerovo State University (RU), Hologic (Germany) (DE)
Openalex Percentile: Top 78%
Metabolomics and Mass Spectrometry Studies
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