Mitogenesis, mitophagy and regulation of mitochondrial metabolism in health and disease

The state of mitochondrial homeostasis, comprising the processes of mitochondrial biogenesis, selective removal of damaged or dysfunctional mitochondria, mitochondrial dynamics (fusion and fission), as well as signaling systems of mitochondrial metabolism regulation are analyzed in this review. Particular attention is paid to how the bioenergetic demands of tissues are modulated in viral SARS-CoV, hepatitis B, C infections and asthma. Keywords: fusion and fission, hepatitis, metabolism, mitochondrial homeostasis, mitogenesis, mitophagy, SARS‑CoV-2