Effects of Chronic Elevation in Plasma Membrane Cholesterol on the Function of Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)
Chronic increases in free cholesterol in the plasma membrane can result in increased or decreased transporter function and expression. In the case of OCT1, which is involved in the uptake of the anti-diabetic drug metformin into hepatocytes, the 3-fold increase in transport capacity might affect drug therapy.
Authors
- Jessica Y. Idowu (ORCID: https://orcid.org/0000-0002-6544-7634)
- Bruno Hagenbuch (ORCID: https://orcid.org/0000-0002-2938-8630)
- Caylie McKimens
Institutions
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Livers
- Published
- 2025-09-12
- DOI
- https://doi.org/10.3390/livers5030045
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00