Flexible glycine-based piezoelectric medical dressing for wound repair

Piezoelectric dressings provide continuous electrical stimulation and accelerate wound healing. However, the trade-off between electromechanical activity and biocompatibility dramatically restricts the clinical promotion of piezoelectric dressings. Herein, we developed glycine–polyvinyl alcohol (Gly–PVA) composite (GPC) via solution casting to address the biocompatibility limitations of conventional piezoelectric materials in implantable applications. Through mass ratio optimization (0.5:1–3:1), the 2:1 Gly–PVA film achieves a piezoelectric coefficient (d33) of 5.2 pC/N and generates 6 V output at 25 N impact with pressure sensitivity of 0.232 V/N while maintaining >92.3% voltage retention after 1000 compression cycles. In a rat wound repair model, GPC-based electroactive dressings elevate Day-7 wound closure to 20%, which significantly exceeds control groups (<14%) through enhanced collagen deposition and reduced inflammation. This work opens up a paradigm for optimization of electroactive properties and biocompatibility in implantable electronics.